Abstract: Under the same flotation process conditions and reagent regime, the flotation characteristics of two frothers (DPM and DPB) with similar chemical structure were investigated from the perspective of the flotation recovery change of lead-zinc minerals. The differences between these two frothers were estimated by analyzing the differences of flotation rates, size distribution of rough concentrates, and the amount of valuable metals. The results showed that the flotation efficiency of the frother DPB was higher than that of DPM. The frother DPB is more favorable for recovering the fine size lead mineral, while the frother DPM is more favorable for recovering the coarse size zinc mineral. Compared with DPM, DPB can improve the grade of lead-zinc concentrate.