Abstract: Taking a gold concentrate containing 45.60 g/t Au and 3.01% Pb as the research object, a process of lead-sulfur flotation separation, regrinding and leaching was finally selected to replace the original regrinding-leaching process based on the technical and economic comparison of beneficiation process. The associated galena was comprehensively recovered with a grade of 56.73% and a recovery of 79.83% in the lead concentrate, and the recoveries of gold and silver were also improved. The total recoveries of gold and silver were 94.55% and 91.67%, respectively, which were 3.85 and 9.42 percentage points higher than those of the original process. The process solves the problem of high production cost from raw ore and the difficulty in recovering fine-grained galena from the leaching residues. Meanwhile, separate grinding and leaching avoids the misplacement of some gold in lead concentrate, thereby effectively improving the comprehensive utilization level of associated resources.