Abstract: Taking galena single mineral as the research object, the effect of grinding on the slurry potential and flotation behavior of galena was investigated by changing grinding conditions with iron sphere and porcelain sphere media. Grinding experiments showed that different grinding media or different grinding conditions (such as grinding time, grinding concentration, pH, CaO dosage) could dramatically change the pulp potential of galena. Flotation experiments showed that the pulp potential directly affected the flotation recovery of galena, and excessively high or low pulp potential is not conducive to flotation. When the potential value of the slurry was kept within the potential range of elemental sulfur, the maximum flotation recovery was achieved.