Abstract: The sulfuric acid curing process of the sulfuric acid method treating lepidolite concentrate, which is the key factor on comprehensive utilization of lithium, rubidium and cesium, was investigated by using L₁₆(4⁵) orthogonal experimental design. The results showed that the importance of the factors affecting the sulfuric acid curing of lepidolite was:acid-solid ratio > sulfuric acid concentration > curing duration > curing temperature > particle size. The optimum curing parameters were determined as follows:acid-solid ratio of 1 GA6FA 1, sulfuric acid concentration of 80%, curing duration of 4 hours, curing temperature of 150℃, particle size of 80% below 74 μm. Under the optimal conditions, the leaching efficiencies of lithium, rubidium and cesium were 97.58%, 96.73% and 97.39%, respectively. The study can provide reference for sulfuric acid method of treating the lepidolite ore, which lays the foundation for the comprehensive utilization of lithium, rubidium and cesium in the lepidolite ore.