Abstract: To explore the effect of different grinding media on the chemical properties of galena ore slurry, the galena in lead-zinc-iron sulfide ore from Guangdong was selected and ground in the porcelain jar using porcelain ball and iron ball, respectively. During grinding, the pulp pH, the pulp potentials Eh, the dissolved oxygen content Do, the pulp temperature and the concentrations of Pb²⁺ and Fe³⁺ in the pulp were measured under different grinding time. According to the principle of local cell action and the galvanic coupling effect, the influence mechanism of two kinds of grinding media on galena slurry properties was analyzed. The results showed that the temperatures of galena ore pulp were basically the same when grinding with porcelain ball and iron ball, and they did not change much with the increase of the grinding time. However, the pulp pH, the pulp potential Eh, the dissolved oxygen content, and the concentrations of Pb²⁺ and Fe³⁺ in the pulp were badly affected by the grinding media, thus influencing the flotation behavior of galena.