Abstract: Zinc ore is an important strategic mineral resource in China. Zinc oxide ore is one of the primary zinc ores. Flotation is the most commonly used method for beneficiation and pretreatment of zinc oxide ores. Due to the high contents of soluble salt and slime, the adverse impact of dissolved ion and slime in the flotation system is notable, which severely restricts the flotation efficiency of zinc oxide ores. The research progress on impacts of dissolved ions and slime in zinc oxide ores flotation system were summarized in this paper. The types and influence laws of dissolved ions and slime as well as the corresponding eliminating method were reviewed in detail. Moreover, the development trends of the research were also discussed. High efficient flotation technology and microcosmic mechanism would be the research trends of the influences of dissolved ions and slime in zinc oxide ores flotation system.