Abstract: The treatment and reuse of mineral processing wastewater in Huize lead-zinc mine are very difficult, because of its enormous output and high levels of harmful impurities. According to the complex sources and characteristics of beneficiation wastewater, gradually, a set of beneficiation wastewater treatment and reuse technology with harmonious complementary model has been formed in the process of production practice and technological transformation. This technology involves the improving wastewater quality for source control, the reducing wastewater capacity for processing control, and the treatment reuse of wastewater for end control. Finally, the treatment and reuse of wastewater in plant achieve zero-discharge of pollutants and improve the utilization of mineral resources. The advanced technology and successful experience could be served as the reference and guidance for wastewater treatment in metallic mineral processing plants.